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Peripheral blood of a patient with CML

Peripheral blood of a patient with CML

The peripheral blood (May-Grünwald-Giemsa stain) of a 27-year old patient with hearing loss showed a massive leukocytosis (680,000/µL) and a marked left shift with a distinct fraction of blast cells. Several eosinophilic cells are clearly visible. Platelets are abundant, although not visible in this part of the blood film. The BCR-ABL fusion gene was detected by FISH analysis of the peripheral blood and secured the diagnosis of CML. Because of the threat of permanent loss of hearing chemotherapy was started within hours after venepuncture (without waiting for the results from bone marrow cytology).

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